Anaphylaxis to serum proteins in the guinea-pig
نویسندگان
چکیده
منابع مشابه
Anaphylaxis in Chopped Guinea Pig Lung
The anaphylactic release of histamine from perfused, chopped guinea pig lung is very sensitive to changes in the NaCl concentration of the containing medium, and it is ionic strength rather than particle concentration which is critical. Consequently, in studies with inhibitors care must be taken to avoid inadvertently increasing ionic strength and thereby misinterpreting the cause of the inhibi...
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The results above reported for total calcium and the membrane-diffusible fraction in the serum of the guinea pig, taken at various intervals during anaphylactic shock, confirm the findings of previous workers that the total calcium is essentially unchanged. There is, however, the further finding that the diffusible fraction is considerably increased over that found for the animal similarly trea...
متن کاملMediators in anaphylaxis of guinea-pig small intestine.
With the use of a nonsensitized segment serving as indicator, the release of histamine or other substances during anaphylactic contraction in the isolated sensitized guinea-pig ileum was demonstrated (1). Histamine release in anaphylaxis was measured by immersing sensitized guinea-pig tissues including the small intestine in Tyrode solution containing the antigen (2,3). Attempts to demonstrate ...
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I. REVIEW OF EARLY CONCEPTS AND EXPERIMENTAL STUDIES. SCOPE T HE HISTORY of the eosinophilic polymorphonuclear leukocytes (referred to as ‘ ‘eosinophils’ ‘ throughout this study) has few landmarks. In 1846, Wharton J ones1 gave the first reliable description of ‘ ‘coarse granules’ ‘ in colorless blood cells. Their morphologic characteristics are so striking that early (Max Schultze2) and recent...
متن کاملRelease of Kallikrein from Guinea Pig Lung during Anaphylaxis
An antigen-antibody reaction occurring in the perfused sensitized guinea pig lung, has been demonstrated to release kallikrein, a proteolytic enzyme related to the formation of kinins. This lung kallikrein is similar to plasma kallikrein in all properties studied, including susceptibility to the same inhibitors, electrophoretic mobility, and heterogeneity in molecular size. The release of kalli...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1944
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1944.sp004045